Stem-cell Return Therapy in Seoul: PRP skin regeneration
This therapy uses platelet-rich plasma (PRP) from your own blood. The growth factors in PRP are used to support the skin’s own repair and regeneration.
Results vary by individual.
Two things decide your Rejuran. We built the clinic around both.
People choosing a Rejuran clinic mostly weigh two things: how much it hurts, and how precisely and closely the injection reaches the dermis. This is where Time Return is strongest.
- Pain: plasma 5-step anesthesia (5A+)
Pick a level from 0+ to 5+ to match your tolerance. Standard numbing cream equals level 0+. Pain tolerance varies.
- Technique: close, even hand injection
A Rejuran result depends on how accurately and densely the injection fills the thin dermis. Ours is tight and even, built on a very large number of cases.
- The evidence
Rejuran SVIP clinic selected by PharmaResearch, 2026 BLACK Membership, 10,000+ cases. By the clinic’s own count, the most Rejuran procedures for a single clinic and a single doctor.
Figures are the clinic’s own. Ask the director for details at your consultation. Results vary by individual.
What the small bumps look like right after Rejuran.
Small raised bumps at the injection points are a common, short-lived reaction while the skin absorbs the product. They usually settle in about 1-3 days, and mild redness in about 1-2 days. It varies by person.
Cheeks and jawline
Same patient, three photos
Photos taken at Time Return Clinic right after Rejuran sessions. Not a promise of results. Results vary by individual. Redness, small bumps or mild swelling can appear after injections. Bleeding, infection and inflammation are possible complications.
Rejuran by hand: many small injections, placed evenly in the dermis.
Rejuran is not one shot. It is many tiny injections across the skin, so the result depends on where each one lands and how evenly the area is covered. That is the second of the two things we build our Rejuran around.
Schematic only, not to scale. Both show the same depth; only the spacing differs.
- 01
What Rejuran puts in
Rejuran contains polynucleotide (PN) from salmon DNA, made by PharmaResearch. In laboratory studies, PN and the related PDRN are linked to adenosine A2A receptor signalling and to more active fibroblasts and matrix production. Human evidence is still more limited.[1]
- 02
Why placement matters
The dermis is thin: about 0.5-2 mm depending on the area. Cadaver and ultrasound work shows that needle length and angle decide whether the product lands inside the dermis or below it. Depth is a choice the hand makes at every point.[2]
- 03
What the “embo” is
Each small injection leaves a tiny raised bump (embo) where the product sits for a short time. At the clinic we see these usually settle in about 1-3 days. Fine needles and serial small injections into the dermis are a common way to place PN: in a 2024 survey of 235 Korean dermatologists, many used a 33G needle and serial puncture.[3] [4]
- 04
How we do it at Time Return
The doctor injects by hand and keeps the points closely and evenly spaced, adjusting depth, pressure and angle point by point. Plasma 5-step anesthesia (5A+) keeps that many-point method comfortable. This is our own approach. Spacing is set by the doctor for each person and area.
Sources
- Polydeoxyribonucleotide in Skincare and Cosmetics: Mechanisms, Therapeutic Applications, and Advancements Beyond Wound Healing and Anti-aging (J Skin Sci Cosmetol)
- Yi et al., Observation on cadavers and through ultrasonography using a 2 mm needle length for intradermal injections (Skin Res Technol, 2023)
- Rho et al., A survey on the cosmetic use of injectable polynucleotide: the pattern of practice among Korean dermatologists (J Cosmet Dermatol, 2024)
- Cavallini et al., Consensus report on the use of PN-HPT (polynucleotides highly purified technology) in aesthetic medicine (J Cosmet Dermatol, 2021)
General statements come from these publications. How Time Return injects is the clinic’s own description. No technique guarantees a result. Results vary by individual.
Creators from around the world filmed their Rejuran visit.
Reels posted by visitors to Time Return Clinic, in English, Japanese, Chinese and more. Tap a card to play the video right here. Opinions are the creators’ own; experiences and results vary from person to person.
One-to-one with the director, not a counselor
The consultation is held by the director in person. Skin thickness, texture and your concern are checked before anything is chosen.
Comfort & access
- Every room is a private one-person roomConsultation and treatment take place in a room used by one patient at a time.
- Airport bus stop at the door, on the ground floorThe clinic is on the 1st floor with a bus stop right in front, so arriving with luggage is easy.
- Interpreters on siteAn interpreter is on site, so you can describe your concerns and ask questions without worry.
Who it is for
- Skin that looks thin, dull or tired
- Skin recovering from irritation or acne
- Anyone who prefers a plan built on their own blood components
- People who want skin regeneration planned alongside Rejuran or lasers
What to expect
- PRP contains growth factors that play a role in wound healing and tissue repair.
- Because it uses your own blood, the doctor explains how it fits your plan at the consultation.
- Results vary by individual. Bleeding, infection or inflammation can occur.
How it works
Blood draw
A small sample of your own blood is taken.
PRP preparation
Platelet-rich plasma is separated from the sample.
Treatment
The doctor places the PRP into the skin where your plan calls for it.
Stem-cell Return Therapy: common questions
What is PRP?
Can I combine it with Rejuran?
Premium Rejuran is Time Return.
Premium Rejuran film 1
Premium Rejuran film 2
Time Return Signature
Plan your Stem-cell Return Therapy visit
Send your skin concern and travel dates. The clinic replies with available times.
Message us your plan